Cell leading edge essay

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In a series of recent works, a new area of research called inverse problems in cell motility has been established. [19] [20] [15] This approach is based on the idea that behavioral or shape changes of a cell bear information about the underlying mechanisms that generate these changes. Reading cell motion, namely, understanding the underlying biophysical and mechanochemical processes, is of paramount importance. [21] [22] The mathematical models developed in these works determine some physical features and material properties of the cells locally through analysis of live cell image sequences and uses this information to make further inferences about the molecular structures, dynamics, and processes within the cells, such as the actin network, microdomains, chemotaxis, adhesion, and retrograde flow.

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The first step of cell movement is protrusion of the leading edge. Undoubtedly, propulsion of the leading edge is a multi-step, complex process [ 18 - 19 , 28 - 33 ], but the basic active mechanism that is believed to move the leading edge is the polymerization of actin filaments towards the cell membrane. Polymerizing actin filaments alone, without any accompanying motors, can generate significant force to move a cell's leading edge. In addition, filament-substrate adhesions are required to prevent the backward movement of polymerizing actin filaments. How does a filament elongating against a load − in this case, the cell membrane and external load, if any − generate such a force?

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cell leading edge essay

Cell leading edge essay

The first step of cell movement is protrusion of the leading edge. Undoubtedly, propulsion of the leading edge is a multi-step, complex process [ 18 - 19 , 28 - 33 ], but the basic active mechanism that is believed to move the leading edge is the polymerization of actin filaments towards the cell membrane. Polymerizing actin filaments alone, without any accompanying motors, can generate significant force to move a cell's leading edge. In addition, filament-substrate adhesions are required to prevent the backward movement of polymerizing actin filaments. How does a filament elongating against a load − in this case, the cell membrane and external load, if any − generate such a force?

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cell leading edge essay

Cell leading edge essay

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cell leading edge essay

Cell leading edge essay

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cell leading edge essay
Cell leading edge essay

The first step of cell movement is protrusion of the leading edge. Undoubtedly, propulsion of the leading edge is a multi-step, complex process [ 18 - 19 , 28 - 33 ], but the basic active mechanism that is believed to move the leading edge is the polymerization of actin filaments towards the cell membrane. Polymerizing actin filaments alone, without any accompanying motors, can generate significant force to move a cell's leading edge. In addition, filament-substrate adhesions are required to prevent the backward movement of polymerizing actin filaments. How does a filament elongating against a load − in this case, the cell membrane and external load, if any − generate such a force?

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Cell leading edge essay

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cell leading edge essay

Cell leading edge essay

In a series of recent works, a new area of research called inverse problems in cell motility has been established. [19] [20] [15] This approach is based on the idea that behavioral or shape changes of a cell bear information about the underlying mechanisms that generate these changes. Reading cell motion, namely, understanding the underlying biophysical and mechanochemical processes, is of paramount importance. [21] [22] The mathematical models developed in these works determine some physical features and material properties of the cells locally through analysis of live cell image sequences and uses this information to make further inferences about the molecular structures, dynamics, and processes within the cells, such as the actin network, microdomains, chemotaxis, adhesion, and retrograde flow.

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cell leading edge essay

Cell leading edge essay

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cell leading edge essay

Cell leading edge essay

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Cell leading edge essay

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