Chloroquine and fluoroquinolone dissertation

Phenyl groups are found in many organic compounds, both natural and synthetic (see figure). Most common among natural products is the amino acid phenylalanine , which contains a phenyl group. A major product of the petrochemical industry is " BTX " consisting of benzene, toluene, and xylene - all of which are building blocks for phenyl compounds. The polymer polystyrene is derived from a phenyl-containing monomer and owes its properties to the rigidity and hydrophobicity of the phenyl groups. Many drugs as well as many pollutants contain phenyl rings. One of the simplest phenyl-containing compounds is phenol , C 6 H 5 OH. It is often said the resonance stability of phenol makes it a stronger acid than that of aliphatic alcohols such as ethanol ( p K a = 10 vs. 16–18). However, a significant contribution is the greater electronegativity of the sp 2 alpha carbon in phenol compared to the sp 3 alpha carbon in aliphatic alcohols. [6]

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The drug should be administered with caution to patients having G-6-PD (glucose-6 phosphate dehydrogenase) deficiency.

In 2003 a novel mechanism was described wherein hydroxychloroquine inhibits stimulation of the toll-like receptor (TLR) 9 family receptors. TLRs are cellular receptors for microbial products that induce inflammatory responses through activation of the innate immune system . [21]

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chloroquine and fluoroquinolone dissertation

Chloroquine and fluoroquinolone dissertation

In 2003 a novel mechanism was described wherein hydroxychloroquine inhibits stimulation of the toll-like receptor (TLR) 9 family receptors. TLRs are cellular receptors for microbial products that induce inflammatory responses through activation of the innate immune system . [21]

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chloroquine and fluoroquinolone dissertation

Chloroquine and fluoroquinolone dissertation

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chloroquine and fluoroquinolone dissertation

Chloroquine and fluoroquinolone dissertation

The drug should be administered with caution to patients having G-6-PD (glucose-6 phosphate dehydrogenase) deficiency.

Action Action

chloroquine and fluoroquinolone dissertation
Chloroquine and fluoroquinolone dissertation

In 2003 a novel mechanism was described wherein hydroxychloroquine inhibits stimulation of the toll-like receptor (TLR) 9 family receptors. TLRs are cellular receptors for microbial products that induce inflammatory responses through activation of the innate immune system . [21]

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Chloroquine and fluoroquinolone dissertation

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chloroquine and fluoroquinolone dissertation

Chloroquine and fluoroquinolone dissertation

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chloroquine and fluoroquinolone dissertation

Chloroquine and fluoroquinolone dissertation

The drug should be administered with caution to patients having G-6-PD (glucose-6 phosphate dehydrogenase) deficiency.

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chloroquine and fluoroquinolone dissertation

Chloroquine and fluoroquinolone dissertation

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Chloroquine and fluoroquinolone dissertation

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Chloroquine and fluoroquinolone dissertation

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